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However, must you happen to miss a Synthroid (thyroxine) dose it’s best to require it as soon as you bear in mind, unless it’s nearly time for an additional dose If your levels are normal, I’d think that a week or two shouldn’t be a big deal. Votes: +2 LI Lizard71 4 Aug 2016. If you are truly hypothyroid, discontinuing your thyroid medication for a longer period of time can have serious consequences. A person can go for many years without thyroid hormones. The body can survive for many years without a thyroid gland. I ended up having to go 9 days without it. Within a few days to weeks, you can expect symptoms of hypothyroidism, including: Fatigue Brain fog Depression and/or anxiety Constipation Dry skin and hair Hair loss Weight gain. I asked if they could get me a refill and they said no. They symptoms are easy enough to identify if your tsh gets too low. How does it take in nutrition meanwhile without the homones? Thyroid removed last year and radioiodine treatment completed. Everyone is different, so it's impossible to say how long one could actually live without thyroid hormones. You should also make sure you have the medication level checked every 3 months, or whenever your doctor tells you to come back because you will likely have symptoms if the level is off either way. You should call the doctor to double check, but if should be fine. I'm concerned how serious this could effect me.. If someone were to have a total thyroidectomy ( removal of all the thyroid gland), it would take weeks or months for the levels of thyroid hor. Have been off synthroid for 3 weeks; 3 weeks left before screening. Org and it will tell you all of the systems it helps regulate. Indeed, people often go undiagnosed for decades despite suffering from hypothyroid symptoms. Was wondering how long the body can sustain life without hormone therapy. Anyways to make a long story short, I had a total thyroidectomy and have been taking synthroid 100mcg (was just dropped down from 112mcg). ETA my daughter was on synthroid for mild hypothyroidism until recently Answer (1 of 11): How long can a body survive without thyroid hormones? I called the pharmacy and got no answers from them either. Any longer than 10-12 hours after your last dose, skip it for that day and take it on your normal schedule the next day You can look up the thyroid in wikipedia.